Mariano del Buono emerges as one of the most famous illuminators in Florence, where he headed a large workshop, collaborating with many Florentine artists of his generation, mainly in the last third of the fifteenth century. After a period in the early 1460s, when he rented a workshop in the Badia Fiorentina, documents suggest that he was a pupil of Bartolomeo Varnucci (c. 1412/1413–1479), who acted as guarantor in 1471 for him on the commission of some illuminated initials for a yet unidentified Antiphonal. His career is roughly divided into two phases. Early on, he distinguished himself by the production of texts with white vine decoration, the borders filled with playful putti and portraits, for example, a Decades of Livy dated 1464 (Florence, Riccardiana Library, Ricc.484) and a Plutarch dated 1469 (Modena, Biblioteca Estense, MS lat. 429). Around the same time, he collaborated with Francesco di Antonio del Chierico (1433–1484) on a De civitate Dei of Saint Augustine for the bookseller Vespasiano da Bisticci (London, British Library, Additional MS 15246). He also collaborated between 1469 and 1470 with Ser Ricciardo di Nanni (active 1449–1480) on a three-volume Livy (Munich, Bayerische Staatsbibliothek, Clm. 15731–15733). A turning point came in the late 1470s, when he worked between 1473 and 1477 on a Breviary for the Ospedale di Santa Maria Nuovo (Florence, Bargello, cod. 68) along with Gherardo di Giovanni di Miniato del Fora (1449 1497) and Girolamo da Cremona. (fl. 1451–1483), the latter an important influence on him. From that point onward, Mariano turned away from white-vine decoration and emphasized the three-dimensionality of the page, filled with landscapes and realistic animals, influenced by works of the Paduan/Ferrara region and the style of Mantegna. Throughout his career, he worked for many important clients: Ferdinand King of Aragon, Lorenzo de’ Medici and his son Piero, and the King of Hungary, Matthias Corvinus; he also enjoyed a special relationship with the Florentine banker, Francesco Sassetti, who commissioned many manuscripts from him. Several devotional books mark the later phase of his career, a Book of Hours for Magalena de’ Medici in 1488 (Waddesdon Manor, Rothschild Collection, MS 16) and an Offiziolo for Ciuliano della Rovere, (Rouen, Bibliothèque municipal, MS A 581 bis).